An Updated Review on Recent Advancements in the Diverse Biological Applications of Medicinally Privileged Scaffold: Chalcone and its derivatives

2022-12-02T12:06:42+00:00

Fused heterocyclic compounds rank among the most significant systems in medicinal chemistry because of their wide-ranging biological effects. Among the various class of compounds, chalcones and their derivatives are found to be one of the important classes in the field of synthetic and pharmaceutical chemistry. These derivatives are mainly synthesized by means of Claisen-Schmidt condensation, Crossed Aldol condensation and Knoevenagel condensation reactions, which provides wider applications in the field of medicine. Due to the broader biological applications like antimicrobial, anticancer, antimalarial, antioxidant, anti-inflammatory, antitubercular, antidiabetic, antileishmanial, anti-vitiligo and neuroprotective properties, these derivatives extended their role in coordination chemistry and also act as intermediates for the synthesis of various organic derivatives containing isoxazole, pyrazole, pyrimidine, naphthalene, indole, polyamine and other moieties as hybrid molecules. The present review discusses the biological applications of various chalcone derivatives. Due to their easiest way of synthesis, nowadays, these types of derivatives were tried for various ailments and by means of implementing various greener chemistry approaches, novel and potent derivatives can be synthesized and applied for various applications. Thus, this review will be helpful for the design of potent chalcone derivatives for numerous applications in the future.

Keywords: Chalcones, 1,3-diphenyl-2-propene-1-one, microbial properties, anticancer, antioxidant, neuroprotective and biological applications

Effects of Oral Hygiene Habits on the Clinical Performance of Tooth-Coloured Posterior Restorations

2023-02-19T11:31:09+00:00

Background: The search for a material that will meet the present-day demands for good aesthetics and functionality has continued to generate interest in dental material sciences. Resinous materials, especially composite resins have no doubt been employed in meeting some of these demands. These restorations like the natural teeth are often exposed to the effect of toothbrushing and other oral hygiene practices.

Objective: The study aimed to assess the effects of toothbrushing on the clinical performance of Resin-based Composites in posterior teeth.

Method: This was a prospective study carried out in the conservative clinic of the University of Benin Teaching Hospital. Following ethical approval, thirty-five patients who had at least three posterior teeth caries and met the inclusion criteria were recruited into the study. The 35 patients then received three restorations each of Organically modified ceramics (ORMOCER), Nanohybrid, and micro-hybrid

Results: Thirty-five participants were recruited for this study. Of the 35 participants, 29 (82.9%) were females while 6 (17.1%) were males, giving a female-to-male ratio of 4:1. Each participant had 3 cavities which were restored with each of the test materials, giving a total of 105 restorations. There was a statistically significant finding with those who brushed using the horizontal technique as well as with those who brushed for a longer duration.

Conclusion: The present study showed that oral hygiene habits especially tooth brushing have effects on the clinical performance of Resin-based Composites, though the effects vary depending on the aspect of toothbrushing.

Keywords: Effects, Oral hygiene, Clinical Performance, Posterior restorations

International Journal of Medical Sciences and Pharma Research

An Updated Review on Recent Advancements in the Diverse Biological Applications of Medicinally Privileged Scaffold: Chalcone and its derivatives

Effects of Oral Hygiene Habits on the Clinical Performance of Tooth-Coloured Posterior Restorations