Preventing Complications in Children: Blood Transfusions in Pediatric HIV Management

Authors

DOI:

https://doi.org/10.22270/ijmspr.v10i3.112

Keywords:

Pediatrics, HIV, blood transfusions, anemia, immune function, HIV management

Abstract

Children living with HIV face unique challenges that significantly impact their health and development, with anemia being one of the most prevalent complications. Blood transfusions have emerged as a vital therapeutic intervention for managing anemia in pediatric HIV patients, providing immediate correction of hemoglobin levels and alleviating debilitating symptoms. This review explores the role of blood transfusions in preventing complications associated with HIV, emphasizing their importance in improving health outcomes and enhancing the quality of life for affected children. The mechanisms through which blood transfusions confer benefits include enhanced oxygen delivery to tissues, improved immune function, and support for growth and development. Clinical evidence highlights the effectiveness of transfusions in reducing hospitalization rates and promoting adherence to antiretroviral therapy (ART). Furthermore, integrating blood transfusions into comprehensive care models fosters a multidisciplinary approach that addresses the medical, nutritional, and psychosocial needs of pediatric patients, ensuring a holistic management strategy.

Keywords: Pediatrics, HIV, blood transfusions, anemia, immune function, HIV management

Author Biography

Emmanuel Ifeanyi Obeagu , Department of Medical Laboratory Science, Kampala International University, Uganda

Department of Medical Laboratory Science, Kampala International University, Uganda

References

Obeagu EI, Obeagu, GU. Counting Cells, Shaping Fates: CD4/CD8 Ratios in HIV. Elite Journal of Scientific Research and Review, 2024; 2(1): 37-50

Obeagu EI, Obeagu GU. Hematological Changes Following Blood Transfusion in Young Children with Severe Malaria and HIV: A Critical Review. Elite Journal of Laboratory Medicine, 2024; 2(1): 33-45

Obeagu EI, Obeagu GU. The Role of Blood Transfusion Strategies in HIV Management: Current Insights and Future Directions. Elite Journal of Medicine, 2024; 2(1):10-22

Obeagu EI, Obeagu GU, Ukibe NR, Oyebadejo SA. Anemia, iron, and HIV: decoding the interconnected pathways: A review. Medicine. 2024;103(2): e36937. https://doi.org/10.1097/MD.0000000000036937 PMid:38215133 PMCid:PMC10783375

Volberding P. The impact of anemia on quality of life in human immunodeficiency virus-infected patients. The Journal of infectious diseases. 2002;185(Supplement_2): S110-114. https://doi.org/10.1086/340198 PMid:12001031

Montoro M, Cucala M, Lanas Á, Villanueva C, Hervás AJ, Alcedo J, Gisbert JP, Aisa ÁP, Bujanda L, Calvet X, Mearin F. Indications and hemoglobin thresholds for red blood cell transfusion and iron replacement in adults with gastrointestinal bleeding: An algorithm proposed by gastroenterologists and patient blood management experts. Frontiers in Medicine. 2022; 9:903739. https://doi.org/10.3389/fmed.2022.903739 PMid:36186804 PMCid:PMC9519983

Obeagu EI, Obeagu GU. Eosinophil Dynamics in Pregnancy among Women Living with HIV: A Comprehensive Review. Int. J. Curr. Res. Med. Sci. 2024;10(1):11-24. https://doi.org/10.22270/ijmspr.v10i2.95

Viola N, Kimono E, Nuruh N, Obeagu EI. Factors Hindering Elimination of Mother to Child Transmission of HIV Service Uptake among HIV Positive Women at Comboni Hospital Kyamuhunga Bushenyi District. Asian Journal of Dental and Health Sciences. 2023;3(2):7-14. https://doi.org/10.22270/ajdhs.v3i2.39

Busch MP, Bloch EM, Kleinman S. Prevention of transfusion-transmitted infections. Blood, The Journal of the American Society of Hematology. 2019;133(17):1854-1864. https://doi.org/10.1182/blood-2018-11-833996 PMid:30808637

Obeagu EI, Obeagu GU. Transfusion-Related Complications in Children Under 5 with Coexisting HIV and Severe Malaria: A Review. Int. J. Curr. Res. Chem. Pharm. Sci. 2024;11(2):9-19.

Obeagu EI, Obeagu GU, Hauwa BA, Umar AI. Neutrophil Dynamics: Unveiling Their Role in HIV Progression within Malaria Patients. Journal home page: http://www. journalijiar. com.;12(01).

Heron SE, Elahi S. HIV infection and compromised mucosal immunity: oral manifestations and systemic inflammation. Frontiers in immunology. 2017; 8:241. https://doi.org/10.3389/fimmu.2017.00241 PMid:28326084 PMCid:PMC5339276

Obeagu EI, Obeagu, GU. P-Selectin and Platelet Activation in HIV: Implications for Antiviral Therapy. Elite Journal of Scientific Research and Review, 2024; 2(1): 17-41

Obeagu EI, Obeagu GU. The Intricate Relationship Between Erythropoietin and HIV-Induced Anemia: Unraveling Pathways for Therapeutic Insights. Int. J. Curr. Res. Chem. Pharm. Sci. 2024;11(2):30-40.

Obeagu EI, Anyiam AF, Obeagu GU. Erythropoietin Therapy in HIV-Infected Individuals: A Critical Review. Elite Journal of HIV, 2024; 2(1): 51-64

Obeagu EI, Obeagu GU. Strength in Unity: Building Support Networks for HIV Patients in Uganda. Elite Journal of Medicine, 2024; 2(1): 1-16

Bloch EM, Vermeulen M, Murphy E. Blood transfusion safety in Africa: a literature review of infectious disease and organizational challenges. Transfusion medicine reviews. 2012;26(2):164-180. https://doi.org/10.1016/j.tmrv.2011.07.006 PMid:21872426 PMCid:PMC3668661

Obeagu EI, Obeagu GU. Eosinophilic Changes in Placental Tissues of HIV-Positive Pregnant Women: A Review. Elite Journal of Laboratory Medicine, 2024; 2(1): 14-32

Obeagu EI, Obeagu, GU. The Crucial Role of Erythropoietin in Managing Anemia in HIV: A Review. Elite Journal of Scientific Research and Review, 2024; 2(1): 24-36

Cunningham-Rundles S, McNeeley DF, Moon A. Mechanisms of nutrient modulation of the immune response. Journal of Allergy and Clinical immunology. 2005;115(6):1119-1128. https://doi.org/10.1016/j.jaci.2005.04.036 PMid:15940121

Obeagu EI, Ubosi NI, Obeagu GU, Obeagu AA. Nutritional Strategies for Enhancing Immune Resilience in HIV: A Review. Int. J. Curr. Res. Chem. Pharm. Sci. 2024;11(2):41-51. https://doi.org/10.22270/ijmspr.v10i2.102

Obeagu EI, Obeagu GU. Assessing Platelet Functionality in HIV Patients Receiving Antiretroviral Therapy: Implications for Risk Assessment. Elite Journal of HIV, 2024; 2(3): 14-26

Obeagu EI, Elamin EAI Obeagu GU. Understanding the Intersection of Highly Active Antiretroviral Therapy and Platelets in HIV Patients: A Review. Elite Journal of Haematology, 2024; 2(3): 111-117

Lotfi R, Kaltenmeier C, Lotze MT, Bergmann C. Until death do us part: necrosis and oxidation promote the tumor microenvironment. Transfusion Medicine and Hemotherapy. 2016 Mar 8;43(2):120-32. https://doi.org/10.1159/000444941 PMid:27226794 PMCid:PMC4872058

Cunha PP, Minogue E, Krause LC, Hess RM, Bargiela D, Wadsworth BJ, Barbieri L, Brombach C, Foskolou IP, Bogeski I, Velica P. Oxygen levels at the time of activation determine T cell persistence and immunotherapeutic efficacy. Elife. 2023;12: e84280. https://doi.org/10.7554/eLife.84280 PMid:37166103 PMCid:PMC10229120

Obeagu EI, Obeagu GU. Neonatal Outcomes in Children Born to Mothers with Severe Malaria, HIV, and Transfusion History: A Review. Elite Journal of Nursing and Health Science, 2024; 2(3): 38-58

Obeagu EI. Erythropoietin and the Immune System: Relevance in HIV Management. Elite Journal of Health Science, 2024; 2(3): 23-35

Zicari S, Sessa L, Cotugno N, Ruggiero A, Morrocchi E, Concato C, Rocca S, Zangari P, Manno EC, Palma P. Immune activation, inflammation, and non-AIDS co-morbidities in HIV-infected patients under long-term ART. Viruses. 2019;11(3):200. https://doi.org/10.3390/v11030200 PMid:30818749 PMCid:PMC6466530

Obeagu EI, Obeagu GU. Understanding Immune Cell Trafficking in Tuberculosis-HIV Coinfection: The Role of L-selectin Pathways. Elite Journal of Immunology, 2024; 2(2): 43-59

Obeagu EI, Obeagu GU. Anemia and Erythropoietin: Key Players in HIV Disease Progression. Elite Journal of Haematology, 2024; 2(3): 42-57

Balderson BH, Grothaus L, Harrison RG, McCoy K, Mahoney C, Catz S. Chronic illness burden and quality of life in an aging HIV population. AIDS care. 2013;25(4):451-458. https://doi.org/10.1080/09540121.2012.712669 PMid:22894702 PMCid:PMC3535557

Obeagu EI, Ayogu EE, Obeagu GU. Impact on Viral Load Dynamics: Understanding the Interplay between Blood Transfusion and Antiretroviral Therapy in HIV Management. Elite Journal of Nursing and Health Science, 2024; 2(2): 5-15

Obeagu EI, Obeagu GU. Immune Modulation in HIV-Positive Neonates: Insights and Implications for Clinical Management. Elite Journal of Nursing and Health Science, 2024; 2(3): 59-72

Chakraborty R, Cannella L, Cottone F, Efficace F. Quality of patient-reported outcome reporting in randomised controlled trials of haematological malignancies according to international quality standards: a systematic review. The Lancet Haematology. 2020;7(12):e892-901. https://doi.org/10.1016/S2352-3026(20)30292-1 PMid:33242446

Hébert PC, Fergusson D, Blajchman MA, Wells GA, Kmetic A, Coyle D, Heddle N, Germain M, Goldman M, Toye B, Schweitzer I. Clinical outcomes following institution of the Canadian universal leukoreduction program for red blood cell transfusions. Jama. 2003;289(15):1941-1949. https://doi.org/10.1001/jama.289.15.1941 PMid:12697796

Vamvakas EC, Blajchman MA. Transfusion-related mortality: the ongoing risks of allogeneic blood transfusion and the available strategies for their prevention. Blood, The Journal of the American Society of Hematology. 2009;113(15):3406-3417. https://doi.org/10.1182/blood-2008-10-167643 PMid:19188662

Kaur P, Basu S. Transfusion-transmitted infections: existing and emerging pathogens. Journal of postgraduate medicine. 2005;51(2):146-151.

Wiersum-Osselton JC, Whitaker B, Grey S, Land K, Perez G, Rajbhandary S, Andrzejewski C, Bolton-Maggs P, Lucero H, Renaudier P, Robillard P. Revised international surveillance case definition of transfusion-associated circulatory overload: a classification agreement validation study. The Lancet Haematology. 2019;6(7):e350-358. https://doi.org/10.1016/S2352-3026(19)30080-8 PMid:31080132

Smit-Sibinga C, Pitman JP. Transmission of HIV through blood-how to bridge the knowledge gap. InHIV and AIDS-Updates on biology, immunology, epidemiology and treatment strategies 2011: 583-618. InTech, Rijeka, Croatia. https://doi.org/10.5772/19618 PMCid:PMC3157305

Slonim AD, Bish EK, Xie RS. Red blood cell transfusion safety: probabilistic risk assessment and cost/benefits of risk reduction strategies. Annals of Operations Research. 2014; 221:377-406. https://doi.org/10.1007/s10479-011-0925-0

Steffen KM, Spinella PC, Holdsworth LM, Ford MA, Lee GM, Asch SM, Proctor EK, Doctor A. Factors influencing implementation of blood transfusion recommendations in pediatric critical care units. Frontiers in Pediatrics. 2021; 9:800461. https://doi.org/10.3389/fped.2021.800461 PMid:34976903 PMCid:PMC8718763

Barro L, Drew VJ, Poda GG, Tagny CT, El‐Ekiaby M, Owusu‐Ofori S, Burnouf T. Blood transfusion in sub‐Saharan Africa: understanding the missing gap and responding to present and future challenges. Vox Sanguinis. 2018;113(8):726-736. https://doi.org/10.1111/vox.12705 PMid:30221365

Ako S, Njunda LA, Akum EA, Benjamin PT, Assob J. Hematological related disorders and transfusion of HIV patients on highly active antiretroviral therapy (HAART) in the South West Region of Cameroon: hematological monitory parameters for HIV follow-up. J HIV Retrovirus. 2018;4(1):5

Published

15-09-2024

How to Cite

Obeagu , E. I. . (2024). Preventing Complications in Children: Blood Transfusions in Pediatric HIV Management. International Journal of Medical Sciences and Pharma Research, 10(3), 35–42. https://doi.org/10.22270/ijmspr.v10i3.112

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